PP6012 Toxicology Online Theory Exam
Order ID |
53563633773 |
Type |
Essay |
Writer Level |
Masters |
Style |
APA |
Sources/References |
4 |
Perfect Number of Pages to Order |
5-10 Pages |
Description/Paper Instructions
PP6012 Toxicology Online Theory Exam
Instruction to Candidates:
- Please log onto the Moodle site PP6012. At 2pm go to the Assessment section. Open the word file called‘PP6012 Exam-1st June 2020’.
- You are presented with the exam paper.Please any one question from section A and any two of the five questions from section B. Each question in a section will carry carries equal marks.
- Open a new word document page for each question on the above document, write your student numberand the question number as indicated.
- Type your answer into this document. You may insert into the document pictures of hand-drawn figures or writing taken with your mobile.
- The exam starts at 2pmand finishes at 5pm. Save the word document using your student number as the file name.You need toupload this file onto the Turnitin link by 5.30pm.
- Upload onto the “PP6012Examination Submission-1stJune 2020” Turnitin site in the Assessment section of the PP6012Moodle site.
- If there are any queries please ask at the beginning and end of the exam. Otherwise text your query on ‘teams’. I will be monitoring from 2pmto 5.30pm.
- The exam paper is shown below
Additional open-book regulations
- Do not copy and paste text or figures from another source (this may incur plagiarism, an academic breach and the assessment can potentially be invalidated).
- Do not attempt to submit the paper more than ONCE on Turnitin to check the similarity levels.
- Only as an approximate guide consider 1000-1500 words for each question. You will not be penalised if you exceed these limits.
Examination Question Paper
Module Code: |
PP6012 |
Component No: |
1 |
Paper Type: |
Exam |
Module Title: |
Toxicology |
Term |
Term 2 |
Level: |
6 |
Credits: |
30 |
Date: |
1st June 2020 |
Time: |
2pm |
Duration: |
3hours |
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PP6012 Toxicology Online Theory Exam Questions
Students are required to answer one question from Section A (40%) and ANY Two questions from Section B (60%).
All questions carry equal marks.
Section A
- Review the role of genetic polymorphism in the metabolism and toxicity of three named compounds.
- Discuss the importance the regulatory process in the development of a new drug.
- Review the importance of the generation of reactive metabolites in xenobiotic mediated toxicity.
- A patient was given a 300mg dose of drug by bolus intravenous injection and plasma concentration determined as displayed in the table below.
Time (h) |
0.5 |
1.0 |
2.0 |
3.0 |
4.0 |
5.0 |
6.0 |
7.0 |
8.0 |
9.0 |
10.0 |
Drug Concentration
(mg/l) |
15 |
13.6 |
11.6 |
10.4 |
9 |
7.8 |
6.7 |
5.8 |
5.2 |
4.5 |
3.6 |
- Plot the data on the graph paper provided [30 Marks].
- Given that kel = slope x 2.303, t1/2 = 0.693/ kel, VD = dose/Co ,
Kel = Co/AUC and Kel = CLtot/ VD determine kel[10 Marks], t1/2 [5 Marks], VD [5 Marks], Co [5 Marks], AUC [10 Marks] and CLtot[5 Marks]
- Comment on the significance of the pharmacokinetic profiles of drugs to their toxic actions [30 Marks]
Section B
2. Critically review the stages in a traditional clinical trial and discuss how these can be modified when there is a need to quickly bring new drugs to the public.
3. Evaluate the factors and mechanisms which make the liver a target for some toxic xenobiotics and how this could be assessed.
4. Using at least two examples, review the role of toxicity testing in the development of a new drug.
5. Review the role xenobiotics play in transforming a normal cell into a cancer cell.
6. Using specific examples review the role of heavy metals in environmental toxicology.
End of Paper
PP6012 Toxicology Online Theory Exam
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PP6012 Toxicology Online Theory Exam
RUBRIC
QUALITY OF RESPONSE |
NO RESPONSE |
POOR / UNSATISFACTORY |
SATISFACTORY |
GOOD |
EXCELLENT |
Content (worth a maximum of 50% of the total points) |
Zero points: Student failed to submit the final paper. |
20 points out of 50: The essay illustrates poor understanding of the relevant material by failing to address or incorrectly addressing the relevant content; failing to identify or inaccurately explaining/defining key concepts/ideas; ignoring or incorrectly explaining key points/claims and the reasoning behind them; and/or incorrectly or inappropriately using terminology; and elements of the response are lacking. |
30 points out of 50: The essay illustrates a rudimentary understanding of the relevant material by mentioning but not full explaining the relevant content; identifying some of the key concepts/ideas though failing to fully or accurately explain many of them; using terminology, though sometimes inaccurately or inappropriately; and/or incorporating some key claims/points but failing to explain the reasoning behind them or doing so inaccurately. Elements of the required response may also be lacking. |
40 points out of 50: The essay illustrates solid understanding of the relevant material by correctly addressing most of the relevant content; identifying and explaining most of the key concepts/ideas; using correct terminology; explaining the reasoning behind most of the key points/claims; and/or where necessary or useful, substantiating some points with accurate examples. The answer is complete. |
50 points: The essay illustrates exemplary understanding of the relevant material by thoroughly and correctly addressing the relevant content; identifying and explaining all of the key concepts/ideas; using correct terminology explaining the reasoning behind key points/claims and substantiating, as necessary/useful, points with several accurate and illuminating examples. No aspects of the required answer are missing. |
Use of Sources (worth a maximum of 20% of the total points). |
Zero points: Student failed to include citations and/or references. Or the student failed to submit a final paper. |
5 out 20 points: Sources are seldom cited to support statements and/or format of citations are not recognizable as APA 6th Edition format. There are major errors in the formation of the references and citations. And/or there is a major reliance on highly questionable. The Student fails to provide an adequate synthesis of research collected for the paper. |
10 out 20 points: References to scholarly sources are occasionally given; many statements seem unsubstantiated. Frequent errors in APA 6th Edition format, leaving the reader confused about the source of the information. There are significant errors of the formation in the references and citations. And/or there is a significant use of highly questionable sources. |
15 out 20 points: Credible Scholarly sources are used effectively support claims and are, for the most part, clear and fairly represented. APA 6th Edition is used with only a few minor errors. There are minor errors in reference and/or citations. And/or there is some use of questionable sources. |
20 points: Credible scholarly sources are used to give compelling evidence to support claims and are clearly and fairly represented. APA 6th Edition format is used accurately and consistently. The student uses above the maximum required references in the development of the assignment. |
Grammar (worth maximum of 20% of total points) |
Zero points: Student failed to submit the final paper. |
5 points out of 20: The paper does not communicate ideas/points clearly due to inappropriate use of terminology and vague language; thoughts and sentences are disjointed or incomprehensible; organization lacking; and/or numerous grammatical, spelling/punctuation errors |
10 points out 20: The paper is often unclear and difficult to follow due to some inappropriate terminology and/or vague language; ideas may be fragmented, wandering and/or repetitive; poor organization; and/or some grammatical, spelling, punctuation errors |
15 points out of 20: The paper is mostly clear as a result of appropriate use of terminology and minimal vagueness; no tangents and no repetition; fairly good organization; almost perfect grammar, spelling, punctuation, and word usage. |
20 points: The paper is clear, concise, and a pleasure to read as a result of appropriate and precise use of terminology; total coherence of thoughts and presentation and logical organization; and the essay is error free. |
Structure of the Paper (worth 10% of total points) |
Zero points: Student failed to submit the final paper. |
3 points out of 10: Student needs to develop better formatting skills. The paper omits significant structural elements required for and APA 6th edition paper. Formatting of the paper has major flaws. The paper does not conform to APA 6th edition requirements whatsoever. |
5 points out of 10: Appearance of final paper demonstrates the student’s limited ability to format the paper. There are significant errors in formatting and/or the total omission of major components of an APA 6th edition paper. They can include the omission of the cover page, abstract, and page numbers. Additionally the page has major formatting issues with spacing or paragraph formation. Font size might not conform to size requirements. The student also significantly writes too large or too short of and paper |
7 points out of 10: Research paper presents an above-average use of formatting skills. The paper has slight errors within the paper. This can include small errors or omissions with the cover page, abstract, page number, and headers. There could be also slight formatting issues with the document spacing or the font Additionally the paper might slightly exceed or undershoot the specific number of required written pages for the assignment. |
10 points: Student provides a high-caliber, formatted paper. This includes an APA 6th edition cover page, abstract, page number, headers and is double spaced in 12’ Times Roman Font. Additionally, the paper conforms to the specific number of required written pages and neither goes over or under the specified length of the paper. |
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