Create a scientific poster using PowerPoint that contains the most important information in the file

Description

Create a scientific poster using PowerPoint that contains the most important information in the fileI

want to use illustrative images, and the poster should be clear and easy to summarize the most important ideas. 

Add images and graphical illustrations of apoptotic pathways and therapeutic targets.

Objective:

The poster aims to present how apoptosis pathways can be targeted to develop novel cancer therapies.

Key Apoptotic Pathways:

Intrinsic Pathway (Mitochondrial Pathway):

Controlled by the Bcl-2 family of proteins, which regulate mitochondrial membrane permeability.

Targeting this pathway can induce apoptosis in cancer cells by promoting the release of cytochrome-c and other pro-apoptotic factors.

Extrinsic Pathway (Death Receptor Pathway):

Involves death receptors like DR4 and DR5 on the cell surface, which trigger apoptosis upon binding with ligands such as TRAIL (TNF-related apoptosis-inducing ligand).

Therapeutics targeting this pathway aim to activate death receptors specifically in cancer cells, sparing normal cells.

Therapeutic Strategies:

Targeting Bcl-2 Family Proteins:

Drugs like Venetoclax (a BH3 mimetic) have been developed to inhibit anti-apoptotic proteins in the Bcl-2 family, promoting apoptosis in cancer cells.

p53 Pathway Targeting:

p53, a tumor suppressor protein, is often mutated in cancers, leading to impaired apoptosis.

Strategies include restoring p53 function through CRISPR/Cas9 or small molecules that refold mutant p53.

Targeting Cancer Stem Cells (CSCs):

CSCs are resistant to traditional therapies and responsible for relapse. Approaches include using TRAIL in combination with chemotherapy to target CSCs and induce apoptosis.